Oligodendroglioma Cells Lack Glutamine Synthetase and Are Auxotrophic for Glutamine, but Do not Depend on Glutamine Anaplerosis for Growth

In cells derived from several types of cancer, a transcriptional program drives high consumption of glutamine (Gln), which is used for anaplerosis, leading to a metabolic addiction for the amino acid. Low or absent expression of Glutamine Synthetase (GS), the only enzyme that catalyzes de novo Gln s...

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Publié dans:Int J Mol Sci
Auteurs principaux: Chiu, Martina, Taurino, Giuseppe, Bianchi, Massimiliano G., Ottaviani, Laura, Andreoli, Roberta, Ciociola, Tecla, Lagrasta, Costanza A. M., Tardito, Saverio, Bussolati, Ovidio
Format: Artigo
Langue:Inglês
Publié: MDPI 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5979401/
https://ncbi.nlm.nih.gov/pubmed/29642388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19041099
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