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Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues

Studies in vitro suggest that mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) attenuates insulin signaling, but confirmation in vivo is lacking since Map4k4 knockout is lethal during embryogenesis. We thus generated mice with floxed Map4k4 alleles and a tamoxifen-inducible Cre/ERT2...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Danai, Laura V., Roth Flach, Rachel J., Virbasius, Joseph V., Garcia Menendez, Lorena, Jung, Dae Young, Kim, Jong Hun, Kim, Jason K., Czech, Michael P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456439/
https://ncbi.nlm.nih.gov/pubmed/25918248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00150-15
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