Glucose addiction of TSC-null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply

The mTORC1 signaling pathway integrates environmental conditions into distinct signals for cell growth by balancing anabolic and catabolic processes. Accordingly, energetic stress inhibits mTORC1 signaling predominantly through AMPK-dependent activation of TSC1/2. Thus, TSC1/2-/- cells are hypersens...

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Detalhes bibliográficos
Main Authors: Choo, Andrew Y., Kim, Sang Gyun, Heiden, Matthew G. Vander, Mahoney, Sarah J., Vu, Hieu, Yoon, Sang-Oh, Cantley, Lewis C., Blenis, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896794/
https://ncbi.nlm.nih.gov/pubmed/20513425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.05.007
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