Glucose addiction of TSC-null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply

The mTORC1 signaling pathway integrates environmental conditions into distinct signals for cell growth by balancing anabolic and catabolic processes. Accordingly, energetic stress inhibits mTORC1 signaling predominantly through AMPK-dependent activation of TSC1/2. Thus, TSC1/2-/- cells are hypersens...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Choo, Andrew Y., Kim, Sang Gyun, Heiden, Matthew G. Vander, Mahoney, Sarah J., Vu, Hieu, Yoon, Sang-Oh, Cantley, Lewis C., Blenis, John
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896794/
https://ncbi.nlm.nih.gov/pubmed/20513425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.05.007
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items