Glucose addiction of TSC-null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply

The mTORC1 signaling pathway integrates environmental conditions into distinct signals for cell growth by balancing anabolic and catabolic processes. Accordingly, energetic stress inhibits mTORC1 signaling predominantly through AMPK-dependent activation of TSC1/2. Thus, TSC1/2-/- cells are hypersens...

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Hlavní autoři: Choo, Andrew Y., Kim, Sang Gyun, Heiden, Matthew G. Vander, Mahoney, Sarah J., Vu, Hieu, Yoon, Sang-Oh, Cantley, Lewis C., Blenis, John
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896794/
https://ncbi.nlm.nih.gov/pubmed/20513425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.05.007
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