Tsc1 regulates tight junction independent of mTORC1

Tuberous sclerosis complex 1 (Tsc1) is a tumor suppressor that functions together with Tsc2 to negatively regulate the mechanistic target of rapamycin complex 1 (mTORC1) activity. Here, we show that Tsc1 has a critical role in the tight junction (TJ) formation of epithelium, independent of its role...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lai, Mingqiang, Zou, Wenchong, Han, Zelong, Zhou, Ling, Qiu, Zeyou, Chen, Juan, Zhang, Sheng, Lai, Pinglin, Li, Kai, Zhang, Yue, Liang, Li, Jiang, Yu, Zou, Zhipeng, Bai, Xiaochun
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325158/
https://ncbi.nlm.nih.gov/pubmed/34301883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020891118
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