TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42

Reorganization of the podosome into the sealing zone is crucial for osteoclasts (OCLs) to resorb bone, but the underlying mechanisms are unclear. Here, we show that tuberous sclerosis complex 1 (TSC1) functions centrally in OCLs to promote podosome organization and bone resorption through mechanisti...

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Udgivet i:Cell Death Differ
Main Authors: Xu, Song, Zhang, Yue, Wang, Jian, Li, Kai, Tan, Kang, Liang, Kangyan, Shen, Junhui, Cai, Daozhang, Jin, Dadi, Li, Mangmang, Xiao, Guozhi, Xu, Jiake, Jiang, Yu, Bai, Xiaochun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143527/
https://ncbi.nlm.nih.gov/pubmed/29358671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-017-0049-4
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