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TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42
Reorganization of the podosome into the sealing zone is crucial for osteoclasts (OCLs) to resorb bone, but the underlying mechanisms are unclear. Here, we show that tuberous sclerosis complex 1 (TSC1) functions centrally in OCLs to promote podosome organization and bone resorption through mechanisti...
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| Publicat a: | Cell Death Differ |
|---|---|
| Autors principals: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6143527/ https://ncbi.nlm.nih.gov/pubmed/29358671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-017-0049-4 |
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