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Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

Metformin has been a first-line treatment for type II diabetes mellitus for decades and is the most widely prescribed antidiabetic drug. Retrospective studies have found that metformin treatment is associated with both reduced cancer diagnoses and cancer-related deaths. Despite the prevalence of met...

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Détails bibliographiques
Auteurs principaux: Luengo, Alba, Sullivan, Lucas B, Heiden, Matthew G Vander
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207883/
https://ncbi.nlm.nih.gov/pubmed/25347702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-014-0082-4
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