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An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis

The mitochondrial electron transport chain (ETC) enables many metabolic processes, but why its inhibition suppresses cell proliferation is unclear. It is also not well understood why pyruvate supplementation allows cells lacking ETC function to proliferate. We used a CRISPR-based genetic screen to i...

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Bibliografiske detaljer
Udgivet i:Cell
Main Authors: Birsoy, Kıvanç, Wang, Tim, Chen, Walter, Freinkman, Elizaveta, Abu-Remaileh, Monther, Sabatini, David M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522279/
https://ncbi.nlm.nih.gov/pubmed/26232224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.07.016
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