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An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis

The mitochondrial electron transport chain (ETC) enables many metabolic processes, but why its inhibition suppresses cell proliferation is unclear. It is also not well understood why pyruvate supplementation allows cells lacking ETC function to proliferate. We used a CRISPR-based genetic screen to i...

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Dades bibliogràfiques
Publicat a:Cell
Autors principals: Birsoy, Kıvanç, Wang, Tim, Chen, Walter, Freinkman, Elizaveta, Abu-Remaileh, Monther, Sabatini, David M.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522279/
https://ncbi.nlm.nih.gov/pubmed/26232224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.07.016
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