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Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells

Mitochondrial respiration is important for cell proliferation, however the specific metabolic requirements fulfilled by respiration to support proliferation have not been defined. Here we show that a major role of respiration in proliferating cells is to provide electron acceptors for aspartate synt...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Sullivan, Lucas B., Gui, Dan Y., Hosios, Aaron M., Bush, Lauren N., Freinkman, Elizaveta, Vander Heiden, Matthew G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522278/
https://ncbi.nlm.nih.gov/pubmed/26232225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.07.017
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