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A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate
Serine is a both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical glucose-derived serine synthesis pathway, Homo sapiens phosphoglycerate dehydrogenase (PHGDH) catalyzes the first, rate-limiting step. Genetic lo...
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| Publicado no: | Nat Chem Biol |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4871733/ https://ncbi.nlm.nih.gov/pubmed/27110680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2070 |
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