Increased PHGDH expression promotes aberrant melanin accumulation

BACKGROUND: Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas. METHODS: In order to study the effect of increased PHGDH expression in tissues in vivo, we gener...

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Vydáno v:BMC Cancer
Hlavní autoři: Mattaini, Katherine R., Sullivan, Mark R., Lau, Allison N., Fiske, Brian P., Bronson, Roderick T., Vander Heiden, Matthew G.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6647269/
https://ncbi.nlm.nih.gov/pubmed/31331318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-5933-5
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