Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

Recent epidemiological and laboratory-based studies suggest that the anti-diabetic drug metformin prevents cancer progression. How metformin diminishes tumor growth is not fully understood. In this study, we report that in human cancer cells, metformin inhibits mitochondrial complex I (NADH dehydrog...

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Detalhes bibliográficos
Main Authors: Wheaton, William W, Weinberg, Samuel E, Hamanaka, Robert B, Soberanes, Saul, Sullivan, Lucas B, Anso, Elena, Glasauer, Andrea, Dufour, Eric, Mutlu, Gokhan M, Budigner, GR Scott, Chandel, Navdeep S
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Human Biology and Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017650/
https://ncbi.nlm.nih.gov/pubmed/24843020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02242
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