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The mitochondrial respiratory chain is required for organismal adaptation to hypoxia

Hypoxia-Inducible Factors (HIFs) are crucial for cellular and organismal adaptation to hypoxia. The mitochondrial respiratory chain is the largest consumer of oxygen in most mammalian cells; however, it is unknown whether the respiratory chain is necessary for in vivo activation of HIFs and organism...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Hamanaka, Robert B., Weinberg, Samuel E., Reczek, Colleen R., Chandel, Navdeep S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838509/
https://ncbi.nlm.nih.gov/pubmed/27068470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.03.044
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