The mitochondrial respiratory chain is essential for haematopoietic stem cell function

Adult and fetal hematopoietic stem cells (HSCs) display a glycolytic phenotype, which is required for maintenance of stemness; however, whether mitochondrial respiration is required to maintain HSC function is not known. Here we report that loss of the mitochondrial complex III subunit Rieske iron s...

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Publicado no:Nat Cell Biol
Main Authors: Ansó, Elena, Weinberg, Samuel E., Diebold, Lauren P., Thompson, Benjamin J., Malinge, Sébastien, Schumacker, Paul T., Liu, Xin, Zhang, Yuannyu, Shao, Zhen, Steadman, Mya, Marsh, Kelly M., Xu, Jian, Crispino, John D., Chandel, Navdeep S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474760/
https://ncbi.nlm.nih.gov/pubmed/28504706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3529
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