Mitochondrial complex III is essential for regulatory T cell suppressive function

Regulatory T cells (T(reg) cells), a distinct subset of CD4(+) T cells, are necessary for the maintenance of immune self-tolerance and homeostasis(1,2). Recent studies have demonstrated that T(reg) cells exhibit a unique metabolic profile characterized by an increase in mitochondrial metabolism rela...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Weinberg, Samuel E., Singer, Benjamin D., Steinert, Elizabeth M., Martinez, Carlos A., Mehta, Manan M., Martínez-Reyes, Inmaculada, Gao, Peng, Helmin, Kathryn A., Abdala-Valencia, Hiam, Sena, Laura A., Schumacker, Paul T., Turka, Laurence A., Chandel, Navdeep S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345596/
https://ncbi.nlm.nih.gov/pubmed/30626970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0846-z
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