Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function

Tregs require Foxp3 expression and induction of a specific DNA hypomethylation signature during development, after which Tregs persist as a self-renewing population that regulates immune system activation. Whether maintenance DNA methylation is required for Treg lineage development and stability and...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Helmin, Kathryn A., Morales-Nebreda, Luisa, Acosta, Manuel A. Torres, Anekalla, Kishore R., Chen, Shang-Yang, Abdala-Valencia, Hiam, Politanska, Yuliya, Cheresh, Paul, Akbarpour, Mahzad, Steinert, Elizabeth M., Weinberg, Samuel E., Singer, Benjamin D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710299/
https://ncbi.nlm.nih.gov/pubmed/32897881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI137712
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