Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Otto Warburg's theory on the origins of cancer postulates that tumor cells have defects in mitochondrial oxidative phosphorylation and therefore rely on high levels of aerobic glycolysis as the major source of ATP to fuel cellular proliferation (the Warburg effect). This is in contrast to norma...

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Bibliographic Details
Main Authors: Weinberg, Frank, Hamanaka, Robert, Wheaton, William W., Weinberg, Samuel, Joseph, Joy, Lopez, Marcos, Kalyanaraman, Balaraman, Mutlu, Gökhan M., Budinger, G. R. Scott, Chandel, Navdeep S.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889315/
https://ncbi.nlm.nih.gov/pubmed/20421486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003428107
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