Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

AMP-activated protein kinase (AMPK) is a sensor of cellular energy status found in metazoans that is known to be activated by stimuli that increase the cellular AMP/ATP ratio. Full activation of AMPK requires specific phosphorylation within the activation loop of the catalytic domain of the α-subuni...

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Библиографические подробности
Главные авторы: Emerling, Brooke M., Weinberg, Frank, Snyder, Colleen, Burgess, Zach, Mutlu, Gökhan M., Viollet, Benoit, Budinger, G.R. Scott, Chandel, Navdeep S.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326346/
https://ncbi.nlm.nih.gov/pubmed/19268526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2009.02.019
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