The proto-oncometabolite fumarate binds glutathione to amplify ROS dependent signaling

The tricarboxylic acid cycle enzyme fumarate hydratase (FH) has been identified as a tumor suppressor in a subset of human renal cell carcinomas. Human FH deficient cancer cells display high fumarate concentration and ROS levels along with activation of HIF-1. The underlying mechanisms by which FH l...

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Détails bibliographiques
Auteurs principaux: Sullivan, Lucas B., Garcia-Martinez, Eva, Nguyen, Hien, Mullen, Andrew R., Dufour, Eric, Sudarshan, Sunil, Licht, Jonathan D., Deberardinis, Ralph J., Chandel, Navdeep S.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775267/
https://ncbi.nlm.nih.gov/pubmed/23747014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.05.003
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