The Oncometabolite Fumarate Promotes Pseudohypoxia Through Noncanonical Activation of NF-κB Signaling

Inactivating mutations of the gene encoding the tricarboxylic acid cycle enzyme fumarate hydratase (FH) have been linked to an aggressive variant of hereditary kidney cancer (hereditary leiomyomatosis and renal cell cancer). These tumors accumulate markedly elevated levels of fumarate. Fumarate is a...

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Detalhes bibliográficos
Main Authors: Shanmugasundaram, Karthigayan, Nayak, Bijaya, Shim, Eun-Hee, Livi, Carolina B., Block, Karen, Sudarshan, Sunil
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148891/
https://ncbi.nlm.nih.gov/pubmed/25028521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568162
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