EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

Ischemic preconditioning is the phenomenon whereby brief periods of sublethal ischemia protect against a subsequent, more prolonged, ischemic insult. In remote ischemic preconditioning (RIPC), ischemia to one organ protects others organs at a distance. We created mouse models to ask if inhibition of...

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Bibliographic Details
Published in:Cell
Main Authors: Olenchock, Benjamin A., Moslehi, Javid, Baik, Alan H., Davidson, Shawn M., Williams, Jeremy, Gibson, William J., Chakraborty, Abhishek A., Pierce, Kerry A., Miller, Christine M., Hanse, Eric A., Kelekar, Ameeta, Sullivan, Lucas B., Wagers, Amy J., Clish, Clary B., Vander Heiden, Matthew G., Kaelin, William G.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819986/
https://ncbi.nlm.nih.gov/pubmed/26919427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.02.006
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