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Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
Reductively metabolized glutamine is a major cellular carbon source for fatty acid synthesis during hypoxia or when mitochondrial respiration is impaired. Yet, a mechanistic understanding of what determines reductive metabolism is missing. Here we identify several cellular conditions where the α-ket...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3934748/ https://ncbi.nlm.nih.gov/pubmed/23900562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3236 |
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