Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Acetyl coenzyme A (AcCoA) is the central biosynthetic precursor for fatty acid synthesis and protein acetylation. In the conventional view of mammalian cell metabolism, AcCoA is primarily generated from glucose-derived pyruvate through the citrate shuttle and adenosine triphosphate citrate lyase (AC...

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Main Authors: Metallo, Christian M., Gameiro, Paulo A., Bell, Eric L., Mattaini, Katherine R., Yang, Juanjuan, Hiller, Karsten, Jewell, Christopher M., Johnson, Zachary R., Irvine, Darrell J., Guarente, Leonard, Kelleher, Joanne K., Vander Heiden, Matthew G., Iliopoulos, Othon, Stephanopoulos, Gregory
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710581/
https://ncbi.nlm.nih.gov/pubmed/22101433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10602
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