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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Acetyl coenzyme A (AcCoA) is the central biosynthetic precursor for fatty acid synthesis and protein acetylation. In the conventional view of mammalian cell metabolism, AcCoA is primarily generated from glucose-derived pyruvate through the citrate shuttle and adenosine triphosphate citrate lyase (AC...
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| Autors principals: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3710581/ https://ncbi.nlm.nih.gov/pubmed/22101433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10602 |
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