Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Acetyl coenzyme A (AcCoA) is the central biosynthetic precursor for fatty acid synthesis and protein acetylation. In the conventional view of mammalian cell metabolism, AcCoA is primarily generated from glucose-derived pyruvate through the citrate shuttle and adenosine triphosphate citrate lyase (AC...

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Bibliografiske detaljer
Main Authors: Metallo, Christian M., Gameiro, Paulo A., Bell, Eric L., Mattaini, Katherine R., Yang, Juanjuan, Hiller, Karsten, Jewell, Christopher M., Johnson, Zachary R., Irvine, Darrell J., Guarente, Leonard, Kelleher, Joanne K., Vander Heiden, Matthew G., Iliopoulos, Othon, Stephanopoulos, Gregory
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710581/
https://ncbi.nlm.nih.gov/pubmed/22101433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10602
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