Cofactor Balance by Nicotinamide Nucleotide Transhydrogenase (NNT) Coordinates Reductive Carboxylation and Glucose Catabolism in the Tricarboxylic Acid (TCA) Cycle

Cancer and proliferating cells exhibit an increased demand for glutamine-derived carbons to support anabolic processes. In addition, reductive carboxylation of α-ketoglutarate by isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) was recently shown to be a major source of citrate synthesis from glutamin...

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Detalhes bibliográficos
Main Authors: Gameiro, Paulo A., Laviolette, Laura A., Kelleher, Joanne K., Iliopoulos, Othon, Stephanopoulos, Gregory
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642339/
https://ncbi.nlm.nih.gov/pubmed/23504317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.396796
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