In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation

Hypoxic and VHL-deficient cells use glutamine to generate citrate and lipids through reductive carboxylation (RC) of α-ketoglutarate. To gain insights into the role of HIF and the molecular mechanisms underlying RC, we took advantage of a panel of disease-associated VHL mutants and showed that HIF e...

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Autori principali: Gameiro, Paulo A., Yang, Juanjuan, Metelo, Ana M., Pérez-Carro, Rocio, Baker, Rania, Wang, Zongwei, Arreola, Alexandra, Rathmell, W. Kimryn, Olumi, Aria, López-Larrubia, Pilar, Stephanopoulos, Gregory, Iliopoulos, Othon
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003458/
https://ncbi.nlm.nih.gov/pubmed/23473032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.02.002
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