Pharmacological HIF2α inhibition improves VHL disease–associated phenotypes in zebrafish model

Patients with a germline mutation in von Hippel-Lindau (VHL) develop renal cell cancers and hypervascular tumors of the brain, adrenal glands, and pancreas as well as erythrocytosis. These phenotypes are driven by aberrant expression of HIF2α, which induces expression of genes involved in cell proli...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Clin Invest
मुख्य लेखकों: Metelo, Ana Martins, Noonan, Haley R., Li, Xiang, Jin, Youngnam, Baker, Rania, Kamentsky, Lee, Zhang, Yiyun, van Rooijen, Ellen, Shin, Jordan, Carpenter, Anne E., Yeh, Jing-Ruey, Peterson, Randall T., Iliopoulos, Othon
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Clinical Investigation 2015
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463187/
https://ncbi.nlm.nih.gov/pubmed/25866969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73665
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