Pharmacological HIF2α inhibition improves VHL disease–associated phenotypes in zebrafish model

Patients with a germline mutation in von Hippel-Lindau (VHL) develop renal cell cancers and hypervascular tumors of the brain, adrenal glands, and pancreas as well as erythrocytosis. These phenotypes are driven by aberrant expression of HIF2α, which induces expression of genes involved in cell proli...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Clin Invest
Päätekijät: Metelo, Ana Martins, Noonan, Haley R., Li, Xiang, Jin, Youngnam, Baker, Rania, Kamentsky, Lee, Zhang, Yiyun, van Rooijen, Ellen, Shin, Jordan, Carpenter, Anne E., Yeh, Jing-Ruey, Peterson, Randall T., Iliopoulos, Othon
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463187/
https://ncbi.nlm.nih.gov/pubmed/25866969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73665
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