Pharmacological HIF2α inhibition improves VHL disease–associated phenotypes in zebrafish model

Patients with a germline mutation in von Hippel-Lindau (VHL) develop renal cell cancers and hypervascular tumors of the brain, adrenal glands, and pancreas as well as erythrocytosis. These phenotypes are driven by aberrant expression of HIF2α, which induces expression of genes involved in cell proli...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Metelo, Ana Martins, Noonan, Haley R., Li, Xiang, Jin, Youngnam, Baker, Rania, Kamentsky, Lee, Zhang, Yiyun, van Rooijen, Ellen, Shin, Jordan, Carpenter, Anne E., Yeh, Jing-Ruey, Peterson, Randall T., Iliopoulos, Othon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463187/
https://ncbi.nlm.nih.gov/pubmed/25866969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73665
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