Mitochondrial metabolism in TCA cycle mutant cancer cells

od Sullivan, Lucas B, Chandel, Navdeep S
Izdano 2014

Mitochondrial reactive oxygen species and cancer

od Sullivan, Lucas B, Chandel, Navdeep S
Izdano u Cancer Metab (2014)

Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

od Luengo, Alba, Sullivan, Lucas B, Heiden, Matthew G Vander
Izdano 2014

Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells

od Sullivan, Lucas B., Gui, Dan Y., Hosios, Aaron M., Bush, Lauren N., Freinkman, Elizaveta, Vander Heiden, Matthew G.
Izdano u Cell (2015)

The proto-oncometabolite fumarate binds glutathione to amplify ROS dependent signaling

od Sullivan, Lucas B., Garcia-Martinez, Eva, Nguyen, Hien, Mullen, Andrew R., Dufour, Eric, Sudarshan, Sunil, Licht, Jonathan D., Deberardinis, Ralph J., Chandel, Navdeep S.
Izdano 2013

Reductive carboxylation supports growth in tumor cells with defective mitochondria

od Mullen, Andrew R., Wheaton, William W., Jin, Eunsook S., Chen, Pei-Hsuan, Sullivan, Lucas B., Cheng, Tzuling, Yang, Youfeng, Linehan, W. Marston, Chandel, Navdeep S., DeBerardinis, Ralph J.
Izdano 2011

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

od Wheaton, William W, Weinberg, Samuel E, Hamanaka, Robert B, Soberanes, Saul, Sullivan, Lucas B, Anso, Elena, Glasauer, Andrea, Dufour, Eric, Mutlu, Gokhan M, Budigner, GR Scott, Chandel, Navdeep S
Izdano 2014

Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin

od Gui, Dan Y., Sullivan, Lucas B., Luengo, Alba, Hosios, Aaron M., Bush, Lauren N., Gitego, Nadege, Davidson, Shawn M., Freinkman, Elizaveta, Thomas, Craig J., Vander Heiden, Matthew G.
Izdano u Cell Metab (2016)

Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy

od McLellan, Catherine A., Vincent, Benjamin M., Solis, Norma V., Lancaster, Alex K., Sullivan, Lucas B., Hartland, Cathy L., Youngsaye, Willmen, Filler, Scott G., Whitesell, Luke, Lindquist, Susan
Izdano u Nat Chem Biol (2017)

Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects

od Mullen, Andrew R., Hu, Zeping, Shi, Xiaolei, Jiang, Lei, Boroughs, Lindsey K., Kovacs, Zoltan, Boriack, Richard, Rakheja, Dinesh, Sullivan, Lucas B., Linehan, W. Marston, Chandel, Navdeep S., DeBerardinis, Ralph J.
Izdano 2014

Aspartate is an endogenous metabolic limitation for tumour growth

od Sullivan, Lucas B., Luengo, Alba, Danai, Laura V., Bush, Lauren N., Diehl, Frances F., Hosios, Aaron M., Lau, Allison N., Elmiligy, Sarah, Malstrom, Scott, Lewis, Caroline A., Vander Heiden, Matthew G.
Izdano u Nat Cell Biol (2018)

Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes

od Hecht, Vivian C., Sullivan, Lucas B., Kimmerling, Robert J., Kim, Dong-Hwee, Hosios, Aaron M., Stockslager, Max A., Stevens, Mark M., Kang, Joon Ho, Wirtz, Denis, Vander Heiden, Matthew G., Manalis, Scott R.
Izdano u J Cell Biol (2016)

Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes

od Hecht, Vivian C., Sullivan, Lucas B., Kimmerling, Robert J., Kim, Dong-Hwee, Hosios, Aaron M., Stockslager, Max A., Stevens, Mark M., Kang, Joon Ho, Wirtz, Denis, Vander Heiden, Matthew G., Manalis, Scott R.
Izdano u J Exp Med (2016)

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

od Luengo, Alba, Li, Zhaoqi, Gui, Dan Y., Sullivan, Lucas B., Zagorulya, Maria, Do, Brian T., Ferreira, Raphael, Naamati, Adi, Ali, Ahmed, Lewis, Caroline A., Thomas, Craig J., Spranger, Stefani, Matheson, Nicholas J., Vander Heiden, Matthew G.
Izdano u Mol Cell (2020)

MAX functions as a tumor suppressor and rewires metabolism in small cell lung cancer

od Augert, Arnaud, Mathsyaraja, Haritha, Ibrahim, Ali H, Freie, Brian, Geuenich, Michael J, Cheng, Pei-Feng, Alibeckoff, Sydney P, Wu, Nan, Hiatt, Joseph B, Basom, Ryan, Gazdar, Adi, Sullivan, Lucas B, Eisenman, Robert N, MacPherson, David
Izdano u Cancer Cell (2020)

MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme

od Li, Yingzhong, Ivica, Nikola A., Dong, Ting, Papageorgiou, Dimitrios P., He, Yanpu, Brown, Douglas R., Kleyman, Marianna, Hu, Guangan, Chen, Walter W., Sullivan, Lucas B., Del Rosario, Amanda, Hammond, Paula T., Vander Heiden, Matthew G., Chen, Jianzhu
Izdano u Nat Commun (2020)

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

od Olenchock, Benjamin A., Moslehi, Javid, Baik, Alan H., Davidson, Shawn M., Williams, Jeremy, Gibson, William J., Chakraborty, Abhishek A., Pierce, Kerry A., Miller, Christine M., Hanse, Eric A., Kelekar, Ameeta, Sullivan, Lucas B., Wagers, Amy J., Clish, Clary B., Vander Heiden, Matthew G., Kaelin, William G.
Izdano u Cell (2016)

Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer

od Davidson, Shawn M., Papagiannakopoulos, Thales, Olenchock, Benjamin A., Heyman, Julia E., Keibler, Mark A., Luengo, Alba, Bauer, Matthew R., Jha, Abhishek K., O’Brien, James P., Pierce, Kerry A., Gui, Dan Y., Sullivan, Lucas B., Wasylenko, Thomas M., Subbaraj, Lakshmipriya, Chin, Christopher R., Stephanopolous, Gregory, Mott, Bryan T., Jacks, Tyler, Clish, Clary B., Vander Heiden, Matthew G.
Izdano u Cell Metab (2016)

Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis

od Rossmann, Marlies P., Hoi, Karen, Chan, Victoria, Abraham, Brian J., Yang, Song, Mullahoo, James, Papanastasiou, Malvina, Wang, Ying, Elia, Ilaria, Perlin, Julie R., Hagedorn, Elliott J., Hetzel, Sara, Weigert, Raha, Vyas, Sejal, Nag, Partha P., Sullivan, Lucas B., Warren, Curtis R., Dorjsuren, Bilguujin, Greig, Eugenia Custo, Adatto, Isaac, Cowan, Chad A., Schreiber, Stuart L., Young, Richard A., Meissner, Alexander, Haigis, Marcia C., Hekimi, Siegfried, Carr, Steven A., Zon, Leonard I.
Izdano u Science (2021)

A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate

od Pacold, Michael E., Brimacombe, Kyle R., Chan, Sze Ham, Rohde, Jason M., Lewis, Caroline A., Swier, Lotteke J.Y.M., Possemato, Richard, Chen, Walter W., Sullivan, Lucas B., Fiske, Brian P., Cho, Sung Won, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D., Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M., Luengo, Alba, Wang, Amy Q., Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D., Vander Heiden, Matthew G., Shen, Min, Gray, Nathanael S., Boxer, Matthew B., Sabatini, David M.
Izdano u Nat Chem Biol (2016)