Mitochondrial metabolism in TCA cycle mutant cancer cells

מאת Sullivan, Lucas B, Chandel, Navdeep S
יצא לאור 2014

Mitochondrial reactive oxygen species and cancer

מאת Sullivan, Lucas B, Chandel, Navdeep S
הוצא לאור ב Cancer Metab (2014)

Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

מאת Luengo, Alba, Sullivan, Lucas B, Heiden, Matthew G Vander
יצא לאור 2014

Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells

מאת Sullivan, Lucas B., Gui, Dan Y., Hosios, Aaron M., Bush, Lauren N., Freinkman, Elizaveta, Vander Heiden, Matthew G.
הוצא לאור ב Cell (2015)

The proto-oncometabolite fumarate binds glutathione to amplify ROS dependent signaling

מאת Sullivan, Lucas B., Garcia-Martinez, Eva, Nguyen, Hien, Mullen, Andrew R., Dufour, Eric, Sudarshan, Sunil, Licht, Jonathan D., Deberardinis, Ralph J., Chandel, Navdeep S.
יצא לאור 2013

Reductive carboxylation supports growth in tumor cells with defective mitochondria

מאת Mullen, Andrew R., Wheaton, William W., Jin, Eunsook S., Chen, Pei-Hsuan, Sullivan, Lucas B., Cheng, Tzuling, Yang, Youfeng, Linehan, W. Marston, Chandel, Navdeep S., DeBerardinis, Ralph J.
יצא לאור 2011

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

מאת Wheaton, William W, Weinberg, Samuel E, Hamanaka, Robert B, Soberanes, Saul, Sullivan, Lucas B, Anso, Elena, Glasauer, Andrea, Dufour, Eric, Mutlu, Gokhan M, Budigner, GR Scott, Chandel, Navdeep S
יצא לאור 2014

Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin

מאת Gui, Dan Y., Sullivan, Lucas B., Luengo, Alba, Hosios, Aaron M., Bush, Lauren N., Gitego, Nadege, Davidson, Shawn M., Freinkman, Elizaveta, Thomas, Craig J., Vander Heiden, Matthew G.
הוצא לאור ב Cell Metab (2016)

Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy

מאת McLellan, Catherine A., Vincent, Benjamin M., Solis, Norma V., Lancaster, Alex K., Sullivan, Lucas B., Hartland, Cathy L., Youngsaye, Willmen, Filler, Scott G., Whitesell, Luke, Lindquist, Susan
הוצא לאור ב Nat Chem Biol (2017)

Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects

מאת Mullen, Andrew R., Hu, Zeping, Shi, Xiaolei, Jiang, Lei, Boroughs, Lindsey K., Kovacs, Zoltan, Boriack, Richard, Rakheja, Dinesh, Sullivan, Lucas B., Linehan, W. Marston, Chandel, Navdeep S., DeBerardinis, Ralph J.
יצא לאור 2014

Aspartate is an endogenous metabolic limitation for tumour growth

מאת Sullivan, Lucas B., Luengo, Alba, Danai, Laura V., Bush, Lauren N., Diehl, Frances F., Hosios, Aaron M., Lau, Allison N., Elmiligy, Sarah, Malstrom, Scott, Lewis, Caroline A., Vander Heiden, Matthew G.
הוצא לאור ב Nat Cell Biol (2018)

Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes

מאת Hecht, Vivian C., Sullivan, Lucas B., Kimmerling, Robert J., Kim, Dong-Hwee, Hosios, Aaron M., Stockslager, Max A., Stevens, Mark M., Kang, Joon Ho, Wirtz, Denis, Vander Heiden, Matthew G., Manalis, Scott R.
הוצא לאור ב J Cell Biol (2016)

Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes

מאת Hecht, Vivian C., Sullivan, Lucas B., Kimmerling, Robert J., Kim, Dong-Hwee, Hosios, Aaron M., Stockslager, Max A., Stevens, Mark M., Kang, Joon Ho, Wirtz, Denis, Vander Heiden, Matthew G., Manalis, Scott R.
הוצא לאור ב J Exp Med (2016)

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

מאת Luengo, Alba, Li, Zhaoqi, Gui, Dan Y., Sullivan, Lucas B., Zagorulya, Maria, Do, Brian T., Ferreira, Raphael, Naamati, Adi, Ali, Ahmed, Lewis, Caroline A., Thomas, Craig J., Spranger, Stefani, Matheson, Nicholas J., Vander Heiden, Matthew G.
הוצא לאור ב Mol Cell (2020)

MAX functions as a tumor suppressor and rewires metabolism in small cell lung cancer

מאת Augert, Arnaud, Mathsyaraja, Haritha, Ibrahim, Ali H, Freie, Brian, Geuenich, Michael J, Cheng, Pei-Feng, Alibeckoff, Sydney P, Wu, Nan, Hiatt, Joseph B, Basom, Ryan, Gazdar, Adi, Sullivan, Lucas B, Eisenman, Robert N, MacPherson, David
הוצא לאור ב Cancer Cell (2020)

MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme

מאת Li, Yingzhong, Ivica, Nikola A., Dong, Ting, Papageorgiou, Dimitrios P., He, Yanpu, Brown, Douglas R., Kleyman, Marianna, Hu, Guangan, Chen, Walter W., Sullivan, Lucas B., Del Rosario, Amanda, Hammond, Paula T., Vander Heiden, Matthew G., Chen, Jianzhu
הוצא לאור ב Nat Commun (2020)

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

מאת Olenchock, Benjamin A., Moslehi, Javid, Baik, Alan H., Davidson, Shawn M., Williams, Jeremy, Gibson, William J., Chakraborty, Abhishek A., Pierce, Kerry A., Miller, Christine M., Hanse, Eric A., Kelekar, Ameeta, Sullivan, Lucas B., Wagers, Amy J., Clish, Clary B., Vander Heiden, Matthew G., Kaelin, William G.
הוצא לאור ב Cell (2016)

Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer

מאת Davidson, Shawn M., Papagiannakopoulos, Thales, Olenchock, Benjamin A., Heyman, Julia E., Keibler, Mark A., Luengo, Alba, Bauer, Matthew R., Jha, Abhishek K., O’Brien, James P., Pierce, Kerry A., Gui, Dan Y., Sullivan, Lucas B., Wasylenko, Thomas M., Subbaraj, Lakshmipriya, Chin, Christopher R., Stephanopolous, Gregory, Mott, Bryan T., Jacks, Tyler, Clish, Clary B., Vander Heiden, Matthew G.
הוצא לאור ב Cell Metab (2016)

Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis

מאת Rossmann, Marlies P., Hoi, Karen, Chan, Victoria, Abraham, Brian J., Yang, Song, Mullahoo, James, Papanastasiou, Malvina, Wang, Ying, Elia, Ilaria, Perlin, Julie R., Hagedorn, Elliott J., Hetzel, Sara, Weigert, Raha, Vyas, Sejal, Nag, Partha P., Sullivan, Lucas B., Warren, Curtis R., Dorjsuren, Bilguujin, Greig, Eugenia Custo, Adatto, Isaac, Cowan, Chad A., Schreiber, Stuart L., Young, Richard A., Meissner, Alexander, Haigis, Marcia C., Hekimi, Siegfried, Carr, Steven A., Zon, Leonard I.
הוצא לאור ב Science (2021)

A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate

מאת Pacold, Michael E., Brimacombe, Kyle R., Chan, Sze Ham, Rohde, Jason M., Lewis, Caroline A., Swier, Lotteke J.Y.M., Possemato, Richard, Chen, Walter W., Sullivan, Lucas B., Fiske, Brian P., Cho, Sung Won, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D., Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M., Luengo, Alba, Wang, Amy Q., Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D., Vander Heiden, Matthew G., Shen, Min, Gray, Nathanael S., Boxer, Matthew B., Sabatini, David M.
הוצא לאור ב Nat Chem Biol (2016)