Target identification and mechanism of action in chemical biology and drug discovery

por Schenone, Monica, Dančík, Vlado, Wagner, Bridget K, Clemons, Paul A
Publicado en Nat Chem Biol (2013)

Empirical Bayes Analysis of Quantitative Proteomics Experiments

por Margolin, Adam A., Ong, Shao-En, Schenone, Monica, Gould, Robert, Schreiber, Stuart L., Carr, Steven A., Golub, Todd R.
Publicado 2009

Identification of a Novel Regulator of Clostridioides difficile Cortex Formation

por Touchette, Megan H., Benito de la Puebla, Hector, Alves Feliciano, Carolina, Tanenbaum, Benjamin, Schenone, Monica, Carr, Steven A., Shen, Aimee
Publicado en mSphere (2021)

Tetracyclines Modify Translation By Targeting Key Human rRNA Substructures

por Mortison, Jonathan D., Schenone, Monica, Myers, Jacob A., Zhang, Ziyang, Chen, Linfeng, Ciarlo, Christie, Comer, Eamon, Natchiar, S. Kundhavai, Carr, Steven A., Klaholz, Bruno P., Myers, Andrew G.
Publicado en Cell Chem Biol (2018)

The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer

por Gandhi, Minakshi, Groß, Matthias, Holler, Jessica M., Coggins, Si’Ana A., Patil, Nitin, Leupold, Joerg H., Munschauer, Mathias, Schenone, Monica, Hartigan, Christina R., Allgayer, Heike, Kim, Baek, Diederichs, Sven
Publicado en Nat Commun (2020)

Selective killing of cancer cells with a small molecule targeting stress response to ROS

por Raj, Lakshmi, Ide, Takao, Gurkar, Aditi U, Foley, Michael, Schenone, Monica, Li, Xiaoyu, Tolliday, Nicola J., Golub, Todd R., Carr, Steven A., Shamji, Alykhan F., Stern, Andrew M., Mandinova, Anna, Schreiber, Stuart L., Lee, Sam W.
Publicado 2011

Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

por Raj, Lakshmi, Ide, Takao, Gurkar, Aditi U., Foley, Michael, Schenone, Monica, Li, Xiaoyu, Tolliday, Nicola J., Golub, Todd R., Carr, Steven A., Shamji, Alykhan F., Stern, Andrew M., Mandinova, Anna, Schreiber, Stuart L., Lee, Sam W.
Publicado en Nature (2018)

Non-canonical translation via deadenylated 3′UTRs maintains primordial germ cells

por Jin, Youngnam N., Schlueter, Peter J., Jurisch-Yaksi, Nathalie, Lam, Pui-Ying, Jin, Shan, Hwang, Woong Y., Yeh, Jing-Ruey Joanna, Yoshigi, Masaaki, Ong, Shao-En, Schenone, Monica, Hartigan, Christina R., Carr, Steven A., Peterson, Randall T.
Publicado en Nat Chem Biol (2018)

CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1

por Belizaire, Roger, Koochaki, Sebastian H. J., Udeshi, Namrata D., Vedder, Alexis, Sun, Lei, Svinkina, Tanya, Hartigan, Christina, McConkey, Marie, Kovalcik, Veronica, Bizuayehu, Amanuel, Stanclift, Caroline, Schenone, Monica, Carr, Steven A., Padron, Eric, Ebert, Benjamin L.
Publicado en Blood (2021)

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

por Krönke, Jan, Udeshi, Namrata D., Narla, Anupama, Grauman, Peter, Hurst, Slater N., McConkey, Marie, Svinkina, Tanya, Heckl, Dirk, Comer, Eamon, Li, Xiaoyu, Ciarlo, Christie, Hartman, Emily, Munshi, Nikhil, Schenone, Monica, Schreiber, Stuart L., Carr, Steven A., Ebert, Benjamin L.
Publicado 2013

Castration resistance in prostate cancer is mediated by the kinase NEK6

por Choudhury, Atish D., Schinzel, Anna C., Cotter, Maura B., Lis, Rosina T., Labella, Katherine, Lock, Ying Jie, Izzo, Francesca, Guney, Isil, Bowden, Michaela, Li, Yvonne Y., Patel, Jinal, Hartman, Emily, Carr, Steven A., Schenone, Monica, Jaffe, Jacob D., Kantoff, Philip W., Hammerman, Peter S., Hahn, William C.
Publicado en Cancer Res (2016)

TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation

por Graham, Daniel B., Lefkovith, Ariel, Deelen, Patrick, de Klein, Niek, Varma, Mukund, Boroughs, Angela, Desch, A. Nicole, Ng, Aylwin C. Y., Guzman, Gaelen, Schenone, Monica, Petersen, Christine P., Bhan, Atul K., Rivas, Manuel A., Daly, Mark J., Carr, Steven A., Wijmenga, Cisca, Xavier, Ramnik J.
Publicado en Cell Rep (2016)

Identifying the proteins to which small-molecule probes and drugs bind in cells

por Ong, Shao-En, Schenone, Monica, Margolin, Adam A., Li, Xiaoyu, Do, Kathy, Doud, Mary K., Mani, D. R., Kuai, Letian, Wang, Xiang, Wood, John L., Tolliday, Nicola J., Koehler, Angela N., Marcaurelle, Lisa A., Golub, Todd R., Gould, Robert J., Schreiber, Stuart L., Carr, Steven A.
Publicado 2009

C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions

por Mohanan, Vishnu, Nakata, Toru, Desch, A. Nicole, Lévesque, Chloé, Boroughs, Angela, Guzman, Gaelen, Cao, Zhifang, Creasey, Elizabeth, Yao, Junmei, Boucher, Gabrielle, Charron, Guy, Bhan, Atul K., Schenone, Monica, Carr, Steven A., Reinecker, Hans–Christian, Daly, Mark J., Rioux, John D., Lassen, Kara G., Xavier, Ramnik J.
Publicado en Science (2018)

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8/S100A9

por Schneider, Rebekka K., Schenone, Monica, Ferreira, Monica Ventura, Kramann, Rafael, Joyce, Cailin E., Hartigan, Christina, Beier, Fabian, Brümmendorf, Tim H., Gehrming, Ulrich, Platzbecker, Uwe, Büsche, Guntram, Knüchel, Ruth, Chen, Michelle C., Waters, Christopher S., Chen, Edwin, Chu, Lisa P., Novina, Carl D., Lindsley, R. Coleman, Carr, Steven A., Ebert, Benjamin L.
Publicado en Nat Med (2016)

Binding of TMPRSS2-ERG to BAF chromatin remodeling complexes mediates prostate oncogenesis

por Sandoval, Gabriel J., Pulice, John L., Pakula, Hubert, Schenone, Monica A., Takeda, David Y., Pop, Marius, Boulay, Gaylor, Williamson, Kaylyn E., McBride, Matthew J., Pan, Joshua, Pierre, Roodolph St., Hartman, Emily, Garraway, Levi A., Carr, Steven A., Rivera, Miguel N., Li, Zhe, Ronco, Lucienne, Hahn, William C., Kadoch, Cigall
Publicado en Mol Cell (2018)

Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation

por Basak, Anindita, Munschauer, Mathias, Lareau, Caleb A., Montbleau, Kara E., Ulirsch, Jacob C., Hartigan, Christina R., Schenone, Monica, Lian, John, Wang, Yaomei, Huang, Yumin, Wu, Xianfang, Gehrke, Lee, Rice, Charles M., An, Xiuli, Christou, Helen A., Mohandas, Narla, Carr, Steven A., Chen, Jane-Jane, Orkin, Stuart H., Lander, Eric S., Sankaran, Vijay G.
Publicado en Nat Genet (2020)

Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma

por Fulciniti, Mariateresa, Martinez-Lopez, Joaquin, Senapedis, William, Oliva, Stefania, Lakshmi Bandi, Rajya, Amodio, Nicola, Xu, Yan, Szalat, Raphael, Gulla, Annamaria, Samur, Mehmet K., Roccaro, Aldo, Linares, Maria, Cea, Michele, Baloglu, Erkan, Argueta, Christian, Landesman, Yosef, Shacham, Sharon, Liu, Siyuan, Schenone, Monica, Wu, Shiaw-Lin, Karger, Barry, Prabhala, Rao, Anderson, Kenneth C., Munshi, Nikhil C.
Publicado en Blood (2017)

Integrated Genomics of Crohn’s Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy

por Begun, Jakob, Lassen, Kara G., Jijon, Humberto B., Baxt, Leigh A., Goel, Gautam, Heath, Robert J., Ng, Aylwin, Tam, Jenny M., Kuo, Szu-Yu, Villablanca, Eduardo J., Fagbami, Lola, Oosting, Marije, Kumar, Vinod, Schenone, Monica, Carr, Steven A., Joosten, Leo A.B., Vyas, Jatin M., Daly, Mark J., Netea, Mihai G., Brown, Gordon D., Wijmenga, Cisca, Xavier, Ramnik J.
Publicado en Cell Rep (2015)

Identification of cancer cytotoxic modulators of PDE3A by predictive chemogenomics

por de Waal, Luc, Lewis, Timothy A., Rees, Matthew G., Tsherniak, Aviad, Wu, Xiaoyun, Choi, Peter S., Gechijian, Lara, Hartigan, Christina, Faloon, Patrick W., Hickey, Mark J., Tolliday, Nicola, Carr, Steven A., Clemons, Paul A., Munoz, Benito, Wagner, Bridget K., Shamji, Alykhan F., Koehler, Angela N., Schenone, Monica, Burgin, Alex B., Schreiber, Stuart L., Greulich, Heidi, Meyerson, Matthew
Publicado en Nat Chem Biol (2015)