CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1

Casitas B-lineage lymphoma (CBL) encodes an E3 ubiquitin ligase and signaling adaptor that regulates receptor and nonreceptor tyrosine kinases. Recurrent CBL mutations occur in myeloid neoplasms, including 10% to 20% of chronic myelomonocytic leukemia (CMML) cases, and selectively disrupt the protei...

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Bibliografische gegevens
Gepubliceerd in:Blood
Hoofdauteurs: Belizaire, Roger, Koochaki, Sebastian H. J., Udeshi, Namrata D., Vedder, Alexis, Sun, Lei, Svinkina, Tanya, Hartigan, Christina, McConkey, Marie, Kovalcik, Veronica, Bizuayehu, Amanuel, Stanclift, Caroline, Schenone, Monica, Carr, Steven A., Padron, Eric, Ebert, Benjamin L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2021
Onderwerpen:
Myeloid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8063090/
https://ncbi.nlm.nih.gov/pubmed/33512474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006528
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