CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1

Casitas B-lineage lymphoma (CBL) encodes an E3 ubiquitin ligase and signaling adaptor that regulates receptor and nonreceptor tyrosine kinases. Recurrent CBL mutations occur in myeloid neoplasms, including 10% to 20% of chronic myelomonocytic leukemia (CMML) cases, and selectively disrupt the protei...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood
Main Authors: Belizaire, Roger, Koochaki, Sebastian H. J., Udeshi, Namrata D., Vedder, Alexis, Sun, Lei, Svinkina, Tanya, Hartigan, Christina, McConkey, Marie, Kovalcik, Veronica, Bizuayehu, Amanuel, Stanclift, Caroline, Schenone, Monica, Carr, Steven A., Padron, Eric, Ebert, Benjamin L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8063090/
https://ncbi.nlm.nih.gov/pubmed/33512474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006528
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados