Substrate-Free High-Throughput Screening Identifies Selective Inhibitors for Uncharacterized Enzymes

Por Bachovchin, Daniel A., Brown, Steven J., Rosen, Hugh, Cravatt, Benjamin F.
Publicado em 2009

A High-Throughput Cell-Based Gaussia Luciferase Reporter Assay for Identifying Modulators of Fibulin-3 Secretion

Por Hulleman, John D., Brown, Steven J., Rosen, Hugh, Kelly, Jeffery W.
Publicado no J Biomol Screen (2012)

High-throughput Screening for Inhibitors of Sialyl- and Fucosyltransferases

Por Rillahan, Cory D., Brown, Steven J., Register, Amy C., Rosen, Hugh, Paulson, James C.
Publicado em 2011

Design, Synthesis, and In Vitro and In Vivo Evaluation of an (18)F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P(1)) PET Tracer

Por Rosenberg, Adam J., Liu, Hui, Jin, Hongjun, Yue, Xuyi, Riley, Sean, Brown, Steven J., Tu, Zhude
Publicado no J Med Chem (2016)

Novel Inhibitors for PRMT1 Discovered by High–Throughput Screening Using Activity–Based Fluorescence Polarization

Por Dillon, Myles B. C., Bachovchin, Daniel A., Brown, Steven J., Finn, M.G., Rosen, Hugh, Cravatt, Benjamin F., Mowen, Kerri A.
Publicado em 2012

Discovery and Optimization of Sulfonyl Acrylonitriles as Selective, Covalent Inhibitors of Protein Phosphatase Methylesterase-1

Por Bachovchin, Daniel A., Zuhl, Andrea M., Speers, Anna E., Wolfe, Monique R., Weerapana, Eranthie, Brown, Steven J., Rosen, Hugh, Cravatt, Benjamin F.
Publicado em 2011

Novel Selective Allosteric and Bitopic Ligands for the S1P(3) Receptor

Por Jo, Euijung, Bhhatarai, Barun, Repetto, Emanuela, Guerrero, Miguel, Riley, Sean, Brown, Steven J., Kohno, Yasushi, Roberts, Edward, Schürer, Stephan C., Rosen, Hugh
Publicado em 2012

Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a

Por Johnson, Jennifer L., Ramadass, Mahalakshmi, He, Jing, Brown, Steven J., Zhang, Jinzhong, Abgaryan, Lusine, Biris, Nikolaos, Gavathiotis, Evripidis, Rosen, Hugh, Catz, Sergio D.
Publicado no J Biol Chem (2016)

Ligand-binding pocket shape differences between S1P(1) and S1P(3) determine efficiency of chemical probe identification by uHTS

Por Schürer, Stephan C., Brown, Steven J., Cabrera, Pedro Gonzales, Schaeffer, Marie-Therese, Chapman, Jacqueline, Jo, Euijung, Chase, Peter, Spicer, Tim, Hodder, Peter, Rosen, Hugh
Publicado em 2008

A Fluopol-ABPP HTS Assay to Identify PAD Inhibitors

Por Knuckley, Bryan, Jones, Justin E., Bachovchin, Daniel A., Slack, Jessica, Causey, Corey P., Brown, Steven J., Rosen, Hugh, Cravatt, Benjamin F., Thompson, Paul R.
Publicado em 2010

Sphingosine 1-Phosphate Receptor 1 (S1P(1)) Upregulation and Amelioration of Experimental Autoimmune Encephalomyelitis by an S1P(1) Antagonist

Por Cahalan, Stuart M., Gonzalez-Cabrera, Pedro J., Nguyen, Nhan, Guerrero, Miguel, Cisar, Elizabeth A. George, Leaf, Nora B., Brown, Steven J., Roberts, Edward, Rosen, Hugh
Publicado em 2013

Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9)

Por Bachovchin, Daniel A., Wolfe, Monique R., Masuda, Kim, Brown, Steven J., Spicer, Timothy P., Fernandez-Vega, Virneliz, Chase, Peter, Hodder, Peter S., Rosen, Hugh, Cravatt, Benjamin F.
Publicado em 2010

A Sphingosine 1-phosphate receptor 2 selective allosteric agonist

Por Satsu, Hideo, Schaeffer, Marie-Therese, Guerrero, Miguel, Saldana, Adrian, Eberhart, Christina, Hodder, Peter, Cayanan, Charmagne, Schürer, Stephan, Bhhatarai, Barun, Roberts, Ed, Rosen, Hugh, Brown, Steven J.
Publicado em 2013

Chemical proteomic profiling of human methyltransferases

Por Horning, Benjamin D., Suciu, Radu M., Ghadiri, Darian, Ulanovskaya, Olesya, Matthews, Megan L., Lum, Kenneth M., Backus, Keriann, Brown, Steven J., Rosen, Hugh, Cravatt, Benjamin F.
Publicado no J Am Chem Soc (2016)

A global map of lipid-binding proteins and their ligandability in cells

Por Niphakis, Micah J., Lum, Kenneth M., Cognetta, Armand B., Correia, Bruno E., Ichu, Taka-Aki, Olucha, Jose, Brown, Steven J., Kundu, Soumajit, Piscitelli, Fabiana, Rosen, Hugh, Cravatt, Benjamin F.
Publicado no Cell (2015)

Cost-effectiveness of Crohn’s disease post-operative care

Por Wright, Emily K, Kamm, Michael A, Dr Cruz, Peter, Hamilton, Amy L, Ritchie, Kathryn J, Bell, Sally J, Brown, Steven J, Connell, William R, Desmond, Paul V, Liew, Danny
Publicado no World J Gastroenterol (2016)

Confirming Target Engagement for Reversible Inhibitors In Vivo by Kinetically Tuned Activity-Based Probes

Por Adibekian, Alexander, Martin, Brent R., Chang, Jae Won, Hsu, Ku-Lung, Tsuboi, Katsunori, Bachovchin, Daniel A., Speers, Anna E., Brown, Steven J., Spicer, Timothy, Fernandez-Vega, Virneliz, Ferguson, Jill, Hodder, Peter S., Rosen, Hugh, Cravatt, Benjamin F.
Publicado em 2012

Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2)

Por Nagano, Joseph M. G., Hsu, Ku-Lung, Whitby, Landon R., Niphakis, Micah J., Speers, Anna E., Brown, Steven J., Spicer, Timothy, Fernandez-Vega, Virneliz, Ferguson, Jill, Hodder, Peter, Srinivasan, Prabhavathi, Gonzalez, Tara D., Rosen, Hugh, Bahnson, Brian J., Cravatt, Benjamin F.
Publicado em 2012

Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Cond...

Por Sanna, M. Germana, Vincent, Kevin P., Repetto, Emanuela, Nguyen, Nhan, Brown, Steven J., Abgaryan, Lusine, Riley, Sean W., Leaf, Nora B., Cahalan, Stuart M., Kiosses, William B., Kohno, Yasushi, Brown, Joan Heller, McCulloch, Andrew D., Rosen, Hugh, Gonzalez-Cabrera, Pedro J.
Publicado no Mol Pharmacol (2016)

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

Por Plate, Lars, Cooley, Christina B, Chen, John J, Paxman, Ryan J, Gallagher, Ciara M, Madoux, Franck, Genereux, Joseph C, Dobbs, Wesley, Garza, Dan, Spicer, Timothy P, Scampavia, Louis, Brown, Steven J, Rosen, Hugh, Powers, Evan T, Walter, Peter, Hodder, Peter, Wiseman, R Luke, Kelly, Jeffery W
Publicado no eLife (2016)