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Ligand-binding pocket shape differences between S1P(1) and S1P(3) determine efficiency of chemical probe identification by uHTS
We have studied the Sphingosine 1-phosphate (S1P) receptor system to better understand why certain molecular targets within a closely related family are much more tractable when identifying compelling chemical leads. Five medically important G protein-coupled receptors for S1P regulate heart rate, c...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597349/ https://ncbi.nlm.nih.gov/pubmed/18590333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb800051m |
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