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Discovery, synthesis and SAR analysis of novel selective small molecule S1P(4)–R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype

High affinity and selective S1P(4) receptor (S1P(4)–R) small molecule agonists may be important proof-of-principle tools used to clarify the receptor biological function and effects to assess the therapeutic potential of the S1P(4)–R in diverse disease areas including treatment of viral infections a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Urbano, Mariangela, Guerrero, Miguel, Velaparthi, Subash, Crisp, Melissa, Chase, Peter, Hodder, Peter, Schaeffer, Marie-Therese, Brown, Steven, Rosen, Hugh, Roberts, Edward
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209756/
https://ncbi.nlm.nih.gov/pubmed/21982495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.09.049
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