Full pharmacological efficacy of a novel S1P(1) agonist that does not require S1P-like head-group interactions

Strong evidence exists for interactions of zwitterionic phosphate and amine groups in Sphingosine-1 phosphate (S1P) to conserved R and E residues present at the extracellular face of transmembrane-3 (TM3) of S1P receptors. The contribution of R(120) and E(121) for high affinity ligand-receptor inter...

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Main Authors: Gonzalez-Cabrera, Pedro J., Jo, Euijung, Sanna, M. Germana, Brown, Steven, Leaf, Nora, Marsolais, David, Schaeffer, Marie-Therese, Chapman, Jacqueline, Cameron, Michael, Guerrero, Miguel, Roberts, Edward, Rosen, Hugh
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575047/
https://ncbi.nlm.nih.gov/pubmed/18708635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.049783
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