Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a

Neutrophils constitute the first line of cellular defense in response to bacterial and fungal infections and rely on granular proteins to kill microorganisms, but uncontrolled secretion of neutrophil cargos is injurious to the host and should be closely regulated. Thus, increased plasma levels of ne...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Johnson, Jennifer L., Ramadass, Mahalakshmi, He, Jing, Brown, Steven J., Zhang, Jinzhong, Abgaryan, Lusine, Biris, Nikolaos, Gavathiotis, Evripidis, Rosen, Hugh, Catz, Sergio D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207069/
https://ncbi.nlm.nih.gov/pubmed/27702998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.741884
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