Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a

Neutrophils constitute the first line of cellular defense in response to bacterial and fungal infections and rely on granular proteins to kill microorganisms, but uncontrolled secretion of neutrophil cargos is injurious to the host and should be closely regulated. Thus, increased plasma levels of ne...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Johnson, Jennifer L., Ramadass, Mahalakshmi, He, Jing, Brown, Steven J., Zhang, Jinzhong, Abgaryan, Lusine, Biris, Nikolaos, Gavathiotis, Evripidis, Rosen, Hugh, Catz, Sergio D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207069/
https://ncbi.nlm.nih.gov/pubmed/27702998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.741884
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