Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a

Neutrophils constitute the first line of cellular defense in response to bacterial and fungal infections and rely on granular proteins to kill microorganisms, but uncontrolled secretion of neutrophil cargos is injurious to the host and should be closely regulated. Thus, increased plasma levels of ne...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Johnson, Jennifer L., Ramadass, Mahalakshmi, He, Jing, Brown, Steven J., Zhang, Jinzhong, Abgaryan, Lusine, Biris, Nikolaos, Gavathiotis, Evripidis, Rosen, Hugh, Catz, Sergio D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Immunology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207069/
https://ncbi.nlm.nih.gov/pubmed/27702998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.741884
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