Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis

Heterozygous mutations in the NLRP3 gene in patients with cryopyrin associated periodic syndrome (CAPS) lead to hyper-responsive inflammasome function. CAPS is a systemic auto-inflammatory syndrome characterized by the activation of the innate immune system induced by elevated pro-inflammatory cytok...

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Detaylı Bibliyografya
Yayımlandı:Front Cell Infect Microbiol
Asıl Yazarlar: Johnson, Jennifer L., Ramadass, Mahalakshmi, Haimovich, Ariela, McGeough, Matthew D., Zhang, Jinzhong, Hoffman, Hal M., Catz, Sergio D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2017
Konular:
Microbiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732154/
https://ncbi.nlm.nih.gov/pubmed/29322034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2017.00507
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