Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis

Heterozygous mutations in the NLRP3 gene in patients with cryopyrin associated periodic syndrome (CAPS) lead to hyper-responsive inflammasome function. CAPS is a systemic auto-inflammatory syndrome characterized by the activation of the innate immune system induced by elevated pro-inflammatory cytok...

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Detalhes bibliográficos
Publicado no:Front Cell Infect Microbiol
Main Authors: Johnson, Jennifer L., Ramadass, Mahalakshmi, Haimovich, Ariela, McGeough, Matthew D., Zhang, Jinzhong, Hoffman, Hal M., Catz, Sergio D.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732154/
https://ncbi.nlm.nih.gov/pubmed/29322034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2017.00507
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