Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation. Reprogramming of the ER proteostasis environment through genetic activation of the Unfolded Protein Response (UP...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Plate, Lars, Cooley, Christina B, Chen, John J, Paxman, Ryan J, Gallagher, Ciara M, Madoux, Franck, Genereux, Joseph C, Dobbs, Wesley, Garza, Dan, Spicer, Timothy P, Scampavia, Louis, Brown, Steven J, Rosen, Hugh, Powers, Evan T, Walter, Peter, Hodder, Peter, Wiseman, R Luke, Kelly, Jeffery W
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954754/
https://ncbi.nlm.nih.gov/pubmed/27435961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15550
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