Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation. Reprogramming of the ER proteostasis environment through genetic activation of the Unfolded Protein Response (UP...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Plate, Lars, Cooley, Christina B, Chen, John J, Paxman, Ryan J, Gallagher, Ciara M, Madoux, Franck, Genereux, Joseph C, Dobbs, Wesley, Garza, Dan, Spicer, Timothy P, Scampavia, Louis, Brown, Steven J, Rosen, Hugh, Powers, Evan T, Walter, Peter, Hodder, Peter, Wiseman, R Luke, Kelly, Jeffery W
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2016
Assuntos:
Biochemistry
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954754/
https://ncbi.nlm.nih.gov/pubmed/27435961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15550
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