Regulating Secretory Proteostasis Through the Unfolded Protein Response: From Function to Therapy

Por Plate, Lars, Wiseman, R. Luke
Publicado no Trends Cell Biol (2017)

Regulating extracellular proteostasis capacity through the unfolded protein response

Por Genereux, Joseph C, Wiseman, R Luke
Publicado no Prion (2015)

Partitioning Conformational Intermediates Between Competing Refolding and Aggregation Pathways: Insights into Transthyretin Amyloid Disease

Por Wiseman, R. Luke, Powers, Evan T., Kelly, Jeffery W.
Publicado em 2005

YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress

Por Rainbolt, T Kelly, Saunders, Jaclyn M, Wiseman, R Luke
Publicado no EMBO Rep (2015)

Endoplasmic Reticulum Quality Control and Systemic Amyloid Disease: Impacting Protein Stability from the Inside Out

Por Chen, John J., Genereux, Joseph C., Wiseman, R. Luke
Publicado no IUBMB Life (2015)

Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity During Stress

Por Rainbolt, T. Kelly, Lebeau, Justine, Puchades, Cristina, Wiseman, R. Luke
Publicado no Cell Rep (2016)

Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases

Por Ryno, Lisa M, Wiseman, R Luke, Kelly, Jeffery W
Publicado no Curr Opin Chem Biol (2013)

Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import Through Tim17A Degradation

Por Rainbolt, T. Kelly, Atanassova, Neli, Genereux, Joseph C., Wiseman, R. Luke
Publicado em 2013

Modulating protein quality control

Por Plate, Lars, Paxman, Ryan J, Wiseman, R Luke, Kelly, Jeffery W
Publicado no eLife (2016)

Protein energetics in maturation of the early secretory pathway

Por Wiseman, R Luke, Koulov, Atanas, Powers, Evan, Kelly, Jeffery W, Balch, William E
Publicado em 2007

Broadly Applicable Methodology for the Rapid and Dosable Small Molecule-Mediated Regulation of Transcription Factors in Human Cells

Por Shoulders, Matthew D., Ryno, Lisa M., Cooley, Christina B., Kelly, Jeffery W., Wiseman, R. Luke
Publicado em 2013

Chaperones in Neurodegeneration

Por Lindberg, Iris, Shorter, James, Wiseman, R. Luke, Chiti, Fabrizio, Dickey, Chad A., McLean, Pamela J.
Publicado no J Neurosci (2015)

ATF6 Activation Reduces the Secretion and Extracellular Aggregation of Destabilized Variants of an Amyloidogenic Protein

Por Chen, John J., Genereux, Joseph C., Qu, Song, Hulleman, John D., Shoulders, Matthew D., Wiseman, R. Luke
Publicado no Chem Biol (2014)

Targeting Protein Aggregation for the Treatment of Degenerative Diseases

Por Eisele, Yvonne S., Monteiro, Cecilia, Fearns, Colleen, Encalada, Sandra E., Wiseman, R. Luke, Powers, Evan T., Kelly, Jeffery W.
Publicado no Nat Rev Drug Discov (2015)

Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor 1

Por Ryno, Lisa M., Genereux, Joseph C., Naito, Tadasuke, Morimoto, Richard I., Powers, Evan T., Shoulders, Matthew D., Wiseman, R. Luke
Publicado em 2014

Atomic structure of the mitochondrial inner membrane AAA+ protease YME1 reveals the mechanism of substrate processing

Por Puchades, Cristina, Rampello, Anthony J., Shin, Mia, Giuliano, Christopher J., Wiseman, R. Luke, Glynn, Steven E., Lander, Gabriel C.
Publicado no Science (2017)

The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress

Por Lebeau, Justine, Saunders, Jaclyn M., Moraes, Vivian W.R., Madhavan, Aparajita, Madrazo, Nicole, Anthony, Mary C., Wiseman, R. Luke
Publicado no Cell Rep (2018)

Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain

Por Cooley, Christina B., Ryno, Lisa M., Plate, Lars, Morgan, Gareth J., Hulleman, John D., Kelly, Jeffery W., Wiseman, R. Luke
Publicado no Proc Natl Acad Sci U S A (2014)

Flavonol activation defines an unanticipated ligand binding site in the kinase-RNase domain of IRE1

Por Wiseman, R. Luke, Zhang, Yuhong, Lee, Kenneth P. K., Harding, Heather P., Haynes, Cole M., Price, Joshua, Sicheri, Frank, Ron, David
Publicado em 2010

Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor

Por Cole, Kyle S., Grandjean, Julia M. D., Chen, Kenny, Witt, Collin H., O’Day, Johanna, Shoulders, Matthew D., Wiseman, R. Luke, Weerapana, Eranthie
Publicado no Biochemistry (2018)