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Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain
Light-chain amyloidosis (AL) is a degenerative disease characterized by the extracellular aggregation of a destabilized amyloidogenic Ig light chain (LC) secreted from a clonally expanded plasma cell. Current treatments for AL revolve around ablating the cancer plasma cell population using chemother...
Tallennettuna:
| Julkaisussa: | Proc Natl Acad Sci U S A |
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| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2014
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4246986/ https://ncbi.nlm.nih.gov/pubmed/25157167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406050111 |
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