Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain

Light-chain amyloidosis (AL) is a degenerative disease characterized by the extracellular aggregation of a destabilized amyloidogenic Ig light chain (LC) secreted from a clonally expanded plasma cell. Current treatments for AL revolve around ablating the cancer plasma cell population using chemother...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Cooley, Christina B., Ryno, Lisa M., Plate, Lars, Morgan, Gareth J., Hulleman, John D., Kelly, Jeffery W., Wiseman, R. Luke
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246986/
https://ncbi.nlm.nih.gov/pubmed/25157167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406050111
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