ATF6 Activation Reduces the Secretion and Extracellular Aggregation of Destabilized Variants of an Amyloidogenic Protein

Systemic amyloidoses result from the aberrant secretion of destabilized, amyloidogenic proteins to the serum where they aggregate into proteotoxic soluble aggregates and amyloid fibrils. Few therapeutic approaches exist to attenuate extracellular pathologic aggregation of amyloidogenic proteins, nec...

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Publicat a:Chem Biol
Autors principals: Chen, John J., Genereux, Joseph C., Qu, Song, Hulleman, John D., Shoulders, Matthew D., Wiseman, R. Luke
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254654/
https://ncbi.nlm.nih.gov/pubmed/25444553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.09.009
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