Endoplasmic Reticulum Proteostasis Influences the Oligomeric State of an Amyloidogenic Protein Secreted from Mammalian Cells

Transthyretin (TTR) is a tetrameric serum protein associated with multiple systemic amyloid diseases. In these disorders, TTR aggregates in extracellular environments through a mechanism involving rate-limiting dissociation of the tetramer to monomers, which then misfold and aggregate into soluble o...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Chen, John J., Genereux, Joseph C., Suh, Eul Hyun, Vartabedian, Vincent F., Rius, Bibiana, Qu, Song, Dendle, Maria T.A., Kelly, Jeffery W., Wiseman, R. Luke
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108364/
https://ncbi.nlm.nih.gov/pubmed/27720586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.09.001
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados