Endoplasmic Reticulum Proteostasis Influences the Oligomeric State of an Amyloidogenic Protein Secreted from Mammalian Cells

Transthyretin (TTR) is a tetrameric serum protein associated with multiple systemic amyloid diseases. In these disorders, TTR aggregates in extracellular environments through a mechanism involving rate-limiting dissociation of the tetramer to monomers, which then misfold and aggregate into soluble o...

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Udgivet i:Cell Chem Biol
Main Authors: Chen, John J., Genereux, Joseph C., Suh, Eul Hyun, Vartabedian, Vincent F., Rius, Bibiana, Qu, Song, Dendle, Maria T.A., Kelly, Jeffery W., Wiseman, R. Luke
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108364/
https://ncbi.nlm.nih.gov/pubmed/27720586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.09.001
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