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Role of domain interactions in the aggregation of full-length immunoglobulin light chains
Amyloid light-chain (LC) amyloidosis is a protein misfolding disease in which the aggregation of an overexpressed antibody LC from a clonal plasma cell leads to organ toxicity and patient death if left untreated. While the overall dimeric architecture of LC molecules is established, with each LC com...
Gardado en:
| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6338840/ https://ncbi.nlm.nih.gov/pubmed/30598439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817538116 |
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