Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins

Misfolding and aggregation of immunoglobulin light chains (LCs) leads to the degeneration of post-mitotic tissue in the disease immunoglobulin LC amyloidosis (AL). We previously reported the discovery of small molecule kinetic stabilizers of the native dimeric structure of full-length LCs, which slo...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Yan, Nicholas, Santos-Martins, Diogo, Rennella, Enrico, Sanchez, Brittany B., Chen, Jason S., Kay, Lewis E., Wilson, Ian A., Morgan, Gareth J., Forli, Stefano, Kelly, Jeffery W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7402200/
https://ncbi.nlm.nih.gov/pubmed/32631553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127356
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