Getting a handle on glycogen synthase – Its interaction with glycogenin

Por Zeqiraj, Elton, Sicheri, Frank
Publicado no Mol Aspects Med (2015)

Putting the brakes on the unfolded protein response

Por Sicheri, Frank, Silverman, Robert H.
Publicado em 2011

Mechanism of catalysis, E2 recognition, and autoinhibition for the IpaH family of bacterial E3 ubiquitin ligases

Por Keszei, Alexander F. A., Sicheri, Frank
Publicado no Proc Natl Acad Sci U S A (2017)

Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities

Por Teyra, Joan, Ernst, Andreas, Singer, Alex, Sicheri, Frank, Sidhu, Sachdev S.
Publicado no Protein Sci (2019)

Expression and purification of functional human glycogen synthase-1:glycogenin-1 complex in insect cells

Por Hunter, Roger W., Zeqiraj, Elton, Morrice, Nicholas, Sicheri, Frank, Sakamoto, Kei
Publicado no Protein Expr Purif (2015)

CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling

Por Rajakulendran, Thanashan, Sahmi, Malha, Kurinov, Igor, Tyers, Mike, Therrien, Marc, Sicheri, Frank
Publicado em 2008

A Structure-based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-box Ubiquitin Ligases

Por Gorelik, Maryna, Manczyk, Noah, Pavlenco, Alia, Kurinov, Igor, Sidhu, Sachdev S., Sicheri, Frank
Publicado no Structure (2018)

Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases

Por Assadieskandar, Amir, Yu, Caiqun, Maisonneuve, Pierre, Kurinov, Igor, Sicheri, Frank, Zhang, Chao
Publicado no ACS Med Chem Lett (2019)

Phosphorylation of Tyrosine Residues in the Kinase Domain and Juxtamembrane Region Regulates the Biological and Catalytic Activities of Eph Receptors

Por Binns, Kathleen L., Taylor, Paul P., Sicheri, Frank, Pawson, Tony, Holland, Sacha J.
Publicado em 2000

Structural and functional characterization of a ubiquitin variant engineered for tight and specific binding to an alpha‐helical ubiquitin interacting motif

Por Manczyk, Noah, Yates, Bradley P., Veggiani, Gianluca, Ernst, Andreas, Sicheri, Frank, Sidhu, Sachdev S.
Publicado no Protein Sci (2017)

The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency

Por Manczyk, Noah, Veggiani, Gianluca, Teyra, Joan, Strilchuk, Amy W., Sidhu, Sachdev S., Sicheri, Frank
Publicado no Sci Rep (2019)

Conserved Structural Mechanisms for Autoinhibition in IpaH Ubiquitin Ligases

Por Chou, Yang-Chieh, Keszei, Alexander F. A., Rohde, John R., Tyers, Mike, Sicheri, Frank
Publicado em 2012

An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase

Por Orlicky, Stephen, Tang, Xiaojing, Neduva, Victor, Elowe, Nadine, Brown, Eric, Sicheri, Frank, Tyers, Mike
Publicado no Nat Biotechnol (2010)

Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in non-conventional RNA splicing

Por Lee, Kenneth P. K., Dey, Madhusudan, Neculai, Dante, Cao, Chune, Dever, Thomas E., Sicheri, Frank
Publicado em 2008

Structural Basis for Specificity of TGFβ Family Receptor Small Molecule Inhibitors

Por Ogunjimi, Abiodun A., Zeqiraj, Elton, Ceccarelli, Derek F., Sicheri, Frank, Wrana, Jeffrey L., David, Laurent
Publicado no Cell Signal (2011)

Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes

Por Garg, Pankaj, Ceccarelli, Derek F., Keszei, Alexander F.A., Kurinov, Igor, Sicheri, Frank, Sidhu, Sachdev S.
Publicado no J Mol Biol (2019)

Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif

Por Manczyk, Noah, Veggiani, Gianluca, Gish, Gerald D., Yates, Bradley P., Ernst, Andreas, Sidhu, Sachdev S., Sicheri, Frank
Publicado no Protein Sci (2019)

A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases

Por Wiesner, Silke, Wybenga-Groot, Leanne E, Warner, Neil, Lin, Hong, Pawson, Tony, Forman-Kay, Julie D, Sicheri, Frank
Publicado em 2006

The Ubiquitin Binding Region of the Smurf HECT Domain Facilitates Polyubiquitylation and Binding of Ubiquitylated Substrates

Por Ogunjimi, Abiodun A., Wiesner, Silke, Briant, Douglas J., Varelas, Xaralabos, Sicheri, Frank, Forman-Kay, Julie, Wrana, Jeffrey L.
Publicado em 2010

Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase

Por Mittag, Tanja, Marsh, Joseph, Grishaev, Alexander, Orlicky, Stephen, Lin, Hong, Sicheri, Frank, Tyers, Mike, Forman-Kay, Julie D.
Publicado em 2010