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Phosphorylation of Tyrosine Residues in the Kinase Domain and Juxtamembrane Region Regulates the Biological and Catalytic Activities of Eph Receptors

Members of the Eph family of receptor tyrosine kinases exhibit a striking degree of amino acid homology, particularly notable in the kinase and membrane-proximal regions. A mutagenesis approach was taken to address the functions of specific conserved tyrosine residues within these catalytic and juxt...

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Main Authors: Binns, Kathleen L., Taylor, Paul P., Sicheri, Frank, Pawson, Tony, Holland, Sacha J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC85918/
https://ncbi.nlm.nih.gov/pubmed/10848605
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