Molecular Characterization of a Toluene-Degrading Methanogenic Consortium

по Ficker, Monica, Krastel, Kirsten, Orlicky, Stephen, Edwards, Elizabeth
Опубликовано 1999

An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase

по Orlicky, Stephen, Tang, Xiaojing, Neduva, Victor, Elowe, Nadine, Brown, Eric, Sicheri, Frank, Tyers, Mike
Опубликовано в: Nat Biotechnol (2010)

Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase

по Mittag, Tanja, Marsh, Joseph, Grishaev, Alexander, Orlicky, Stephen, Lin, Hong, Sicheri, Frank, Tyers, Mike, Forman-Kay, Julie D.
Опубликовано 2010

Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCF(Cdc4) ubiquitin ligase

по Tang, Xiaojing, Orlicky, Stephen, Mittag, Tanja, Csizmok, Veronika, Pawson, Tony, Forman-Kay, Julie D., Sicheri, Frank, Tyers, Mike
Опубликовано 2012

Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor

по Mittag, Tanja, Orlicky, Stephen, Choy, Wing-Yiu, Tang, Xiaojing, Lin, Hong, Sicheri, Frank, Kay, Lewis E., Tyers, Mike, Forman-Kay, Julie D.
Опубликовано 2008

Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1–F-box interface

по Gorelik, Maryna, Orlicky, Stephen, Sartori, Maria A., Tang, Xiaojing, Marcon, Edyta, Kurinov, Igor, Greenblatt, Jack F., Tyers, Mike, Moffat, Jason, Sicheri, Frank, Sidhu, Sachdev S.
Опубликовано в: Proc Natl Acad Sci U S A (2016)

SCF(Cdc4) Enables Mating Type Switching in Yeast by Cyclin-Dependent Kinase-Mediated Elimination of the Ash1 Transcriptional Repressor

по Liu, Qingquan, Larsen, Brett, Ricicova, Marketa, Orlicky, Stephen, Tekotte, Hille, Tang, Xiaojing, Craig, Karen, Quiring, Adam, Le Bihan, Thierry, Hansen, Carl, Sicheri, Frank, Tyers, Mike
Опубликовано 2011

An allosteric conduit facilitates dynamic multisite substrate recognition by the SCF(Cdc4) ubiquitin ligase

по Csizmok, Veronika, Orlicky, Stephen, Cheng, Jing, Song, Jianhui, Bah, Alaji, Delgoshaie, Neda, Lin, Hong, Mittag, Tanja, Sicheri, Frank, Chan, Hue Sun, Tyers, Mike, Forman-Kay, Julie D.
Опубликовано в: Nat Commun (2017)

E2 enzyme inhibition by stabilization of a low affinity interface with ubiquitin

по Huang, Hao, Ceccarelli, Derek F, Orlicky, Stephen, St-Cyr, Daniel J., Ziemba, Amy, Garg, Pankaj, Plamondon, Serge, Auer, Manfred, Sidhu, Sachdev, Marinier, Anne, Kleiger, Gary, Tyers, Mike, Sicheri, Frank
Опубликовано 2013

OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function

по Juang, Yu-Chi, Landry, Marie-Claude, Sanches, Mario, Vittal, Vinayak, Leung, Charles, Ceccarelli, Derek F., Mateo, Abigail-Rachele F., Pruneda, Jonathan N., Mao, Dan, Szilard, Rachel K., Orlicky, Stephen, Munro, Meagan, Brzovic, Peter S., Klevit, Rachel E., Sicheri, Frank, Durocher, Daniel
Опубликовано 2012

Higher -Order Assembly of BRCC36–KIAA0157 Is Required for DUB Activity and Biological Function

по Zeqiraj, Elton, Tian, Lei, Piggott, Christopher A., Pillon, Monica C., Duffy, Nicole M., Ceccarelli, Derek F., Keszei, Alexander F. A., Lorenzen, Kristina, Kurinov, Igor, Orlicky, Stephen, Gish, Gerald D., Heck, Albert J.R., Guarné, Alba, Greenberg, Roger A., Sicheri, Frank
Опубликовано в: Mol Cell (2015)

Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine

по Mao, Daniel Y.L., Neculai, Dante, Downey, Michael, Orlicky, Stephen, Haffani, Yosr Z., Ceccarelli, Derek F., Ho, Jenny S.L., Szilard, Rachel K., Zhang, Wei, Ho, Cynthia S., Wan, Leo, Fares, Christophe, Rumpel, Sigrun, Kurinov, Igor, Arrowsmith, Cheryl H., Durocher, Daniel, Sicheri, Frank
Опубликовано 2008

A substrate binding model for the KEOPS tRNA modifying complex

по Beenstock, Jonah, Ona, Samara Mishelle, Porat, Jennifer, Orlicky, Stephen, Wan, Leo C. K., Ceccarelli, Derek F., Maisonneuve, Pierre, Szilard, Rachel K., Yin, Zhe, Setiaputra, Dheva, Mao, Daniel Y. L., Khan, Morgan, Raval, Shaunak, Schriemer, David C., Bayfield, Mark A., Durocher, Daniel, Sicheri, Frank
Опубликовано в: Nat Commun (2020)

Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity

по Huang, Hao, Zeqiraj, Elton, Dong, Beihua, Jha, Babal Kant, Duffy, Nicole M., Orlicky, Stephen, Thevakumaran, Neroshan, Talukdar, Manisha, Pillon, Monica C., Ceccarelli, Derek F., Wan, Leo C.K., Juang, Yu-Chi, Mao, Daniel Y.L., Gaughan, Christina, Brinton, Margo A., Perelygin, Andrey A., Kourinov, Igor, Guarné, Alba, Silverman, Robert H., Sicheri, Frank
Опубликовано 2014

Functional characterization of a PROTAC directed against BRAF mutant V600E

по Posternak, Ganna, Tang, Xiaojing, Maisonneuve, Pierre, Jin, Ting, Lavoie, Hugo, Daou, Salima, Orlicky, Stephen, de Rugy, Theo Goullet, Caldwell, Lauren, Chan, Kin, Aman, Ahmed, Prakesch, Michael, Poda, Gennady, Mader, Pavel, Wong, Cassandra, Maier, Stefan, Kitaygorodsky, Julia, Larsen, Brett, Colwill, Karen, Yin, Zhe, Ceccarelli, Derek F., Batey, Robert A., Taipale, Mikko, Kurinov, Igor, Uehling, David, Wrana, Jeff, Durocher, Daniel, Gingras, Anne-Claude, Al-Awar, Rima, Therrien, Marc, Sicheri, Frank
Опубликовано в: Nat Chem Biol (2020)