An allosteric conduit facilitates dynamic multisite substrate recognition by the SCF(Cdc4) ubiquitin ligase

The ubiquitin ligase SCF(Cdc4) mediates phosphorylation-dependent elimination of numerous substrates by binding one or more Cdc4 phosphodegrons (CPDs). Methyl-based NMR analysis of the Cdc4 WD40 domain demonstrates that Cyclin E, Sic1 and Ash1 degrons have variable effects on the primary Cdc4(WD40)...

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Publicat a:Nat Commun
Autors principals: Csizmok, Veronika, Orlicky, Stephen, Cheng, Jing, Song, Jianhui, Bah, Alaji, Delgoshaie, Neda, Lin, Hong, Mittag, Tanja, Sicheri, Frank, Chan, Hue Sun, Tyers, Mike, Forman-Kay, Julie D.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216119/
https://ncbi.nlm.nih.gov/pubmed/28045046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13943
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